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1

Concentrated fed-batch cell culture increases manufacturing capacity without additional volumetric capacity

Yang, William C., Minkler, Daniel F., Kshirsagar, Rashmi, Ryll, Thomas, Huang, Yao-Ming

Journal:

Journal of Biotechnology

Year:

2016

Language:

english

File:

PDF, 459 KB

english, 2016

2

Development of a scale down cell culture model using multivariate analysis as a qualification tool

Tsang, Valerie Liu, Wang, Angela X., Yusuf-Makagiansar, Helena, Ryll, Thomas

Journal:

Biotechnology Progress

Year:

2014

Language:

english

File:

PDF, 523 KB

english, 2014

3

Addition of Valproic Acid to CHO Cell Fed-Batch Cultures Improves Monoclonal Antibody Titers

Yang, William C., Lu, Jiuyi, Nguyen, Ngan B., Zhang, An, Healy, Nicholas V., Kshirsagar, Rashmi, Ryll, Thomas, Huang, Yao-Ming

Journal:

Molecular Biotechnology

Year:

2014

Language:

english

File:

PDF, 349 KB

english, 2014

4

Application of high-throughput mini-bioreactor system for systematic scale-down modeling, process characterization, and control strategy development

Janakiraman, Vijay, Kwiatkowski, Chris, Kshirsagar, Rashmi, Ryll, Thomas, Huang, Yao-Ming

Journal:

Biotechnology Progress

Year:

2015

Language:

english

File:

PDF, 537 KB

english, 2015

5

Advanced process monitoring and feedback control to enhance cell culture process production and robustness

Zhang, An, Tsang, Valerie Liu, Moore, Brandon, Shen, Vivian, Huang, Yao-Ming, Kshirsagar, Rashmi, Ryll, Thomas

Journal:

Biotechnology and Bioengineering

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

6

Therapeutic Fc-Fusion Proteins || Introduction: Antibody Structure and Function

Chamow, Steven M., Ryll, Thomas, Lowman, Henry B., Farson, Deborah

Year:

2014

Language:

english

File:

PDF, 875 KB

english, 2014

7

Comprehensive manipulation of glycosylation profiles across development scales

Loebrich, Sven, Clark, Elisa, Ladd, Kristina, Takahashi, Stefani, Brousseau, Anna, Kitchener, Seth, Herbst, Robert, Ryll, Thomas

Journal:

Year:

2018

Language:

english

File:

PDF, 5.50 MB

english, 2018

8

Investigation of metabolic variability observed in extended fed batch cell culture

Gilbert, Alan, McElearney, Kyle, Kshirsagar, Rashmi, Sinacore, Martin S., Ryll, Thomas

Journal:

Biotechnology Progress

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

9

Control of misincorporation of serine for asparagine during antibody production using CHO cells

Anurag Khetan, Yao-ming Huang, Jana Dolnikova, Nels E. Pederson, Dingyi Wen, Helena Yusuf-Makagiansar, Paul Chen, Thomas Ryll

Journal:

Biotechnology and Bioengineering

Year:

2010

Language:

english

File:

PDF, 3.20 MB

english, 2010

10

A high-throughput capillary isoelectric focusing immunoassay for fingerprinting protein sialylation

Markely, Lam Raga Anggara, Cheung, Lila, Choi, Young Jun, Ryll, Thomas, Estes, Scott, Prajapati, Shashi, Turyan, Iva, Frenkel, Ruth, Sosic, Zoran, Lambropoulos, James, Tescione, Lia, Ryll, Thomas, Ber

Journal:

Biotechnology Progress

Year:

2016

Language:

english

File:

PDF, 467 KB

english, 2016

11

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

Yao-Ming Huang, WeiWei Hu, Eddie Rustandi, Kevin Chang, Helena Yusuf-Makagiansar, Thomas Ryll

Journal:

Biotechnology Progress

Year:

2010

Language:

english

File:

PDF, 698 KB

english, 2010

12

Confined Synthesis and Integration of Functional Materials in Sub-nanoliter Volumes

Cvetković, Benjamin Z., Puigmartí-Luis, Josep, Schaffhauser, Daniel, Ryll, Thomas, Schmid, Stefan, Dittrich, Petra S.

Journal:

Year:

2013

Language:

english

File:

PDF, 4.49 MB

english, 2013

13

Application of Factorial Design to Accelerate Identification of CHO Growth Factor Requirements

Chung Chun, Katy Heineken, Dongmei Szeto, Thomas Ryll, Steve Chamow, John D. Chung

Journal:

Biotechnology Progress

Year:

2003

Language:

english

File:

PDF, 107 KB

english, 2003

14

Practical Implications of Using Real-World Evidence (RWE) in Comparative Effectiveness Research: Learnings from IMI-GetReal

Makady, Amr, Stegenga, Heather, Ciaglia, Antonio, Debray, Thomas PA, Lees, Michael, Happich, Michael, Ryll, Bettina, Abrams, Keith, Thwaites, Rob, Garner, Sarah, Jonsson, Páll, Goettsch, Wim

Journal:

Journal of Comparative Effectiveness Research

Year:

2017

Language:

english

File:

PDF, 2.03 MB

english, 2017

15

Leveraging high-throughput technology to accelerate the time to clinic: A case study of a mAb

Siva, Sethu, Zhang, An, Koepf, Edward, Conley, Lynn, Cecchini, Doug, Huang, Yao-Ming, Kshirsagar, Rashmi, Ryll, Thomas

Journal:

Engineering in Life Sciences

Year:

2016

Language:

english

File:

PDF, 620 KB

english, 2016

16

Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality

Yang, William C., Lu, Jiuyi, Kwiatkowski, Chris, Yuan, Hang, Kshirsagar, Rashmi, Ryll, Thomas, Huang, Yao-Ming

Journal:

Biotechnology Progress

Year:

2014

Language:

english

File:

PDF, 633 KB

english, 2014

17

Metabolic oscillations in an E. coli fermentation

Dana C. Andersen, James Swartz, Thomas Ryll, Norm Lin, Brad Snedecor

Journal:

Biotechnology and Bioengineering

Year:

2001

Language:

english

File:

PDF, 186 KB

english, 2001

18

ChemInform Abstract: Characterization of Thin Films for Solid Oxide Fuel Cells Facilitated by Micropatterning

Thomas Ryll, Jennifer L. M. Rupp, Anja Bieberle-Hutter, Henning Galinski, Ludwig J. Gauckler

Journal:

Year:

2012

File:

PDF, 19 KB

2012

19

Therapeutic Fc-Fusion Proteins || Alefacept

Chamow, Steven M., Ryll, Thomas, Lowman, Henry B., Farson, Deborah

Year:

2014

Language:

english

File:

PDF, 898 KB

english, 2014

20

Micro-solid oxide fuel cells: status, challenges, and chances

Anna Evans, Anja Bieberle-Hütter, Henning Galinski, Jennifer L. M. Rupp, Thomas Ryll, Barbara Scherrer, René Tölke, Ludwig J. Gauckler

Journal:

Monatshefte für Chemie - Chemical Monthly

Year:

2009

Language:

english

File:

PDF, 593 KB

english, 2009

21

Aberrant Metabolic Sialylation of Recombinant Proteins Expressed in Chinese Hamster Ovary Cells in High Productivity Cultures

Lydia Santell, Thomas Ryll, Tina Etcheverry, Michael Santoris, George Dutina, Angie Wang, Jane Gunson, Thomas G. Warner

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 76 KB

english, 1999

22

Heat Inactivation of Mammalian Cell Cultures for Biowaste Kill System Design

Niki Gregoriades, Melissa Luzardo, Beatrice Lucquet, Thomas Ryll

Journal:

Biotechnology Progress

Year:

2003

Language:

english

File:

PDF, 443 KB

english, 2003

23

Therapeutic Fc-Fusion Proteins || Recombinant Factor VIII- and Factor IX-Fc Fusions

Chamow, Steven M., Ryll, Thomas, Lowman, Henry B., Farson, Deborah

Year:

2014

Language:

english

File:

PDF, 677 KB

english, 2014

24

Ammonium alters N-glycan structures of recombinant TNFR-IgG: Degradative versus biosynthetic mechanisms

Martin Gawlitzek, Thomas Ryll, Jim Lofgren, Mary B. Sliwkowski

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 286 KB

english, 2000

25

PilC of Neisseria meningitidis is involved in class II pilus formation and restores pilus assembly, natural transformation competence and adherence to epithelial cells in PilC-deficient gonococci

Roland R. Ryll, Thomas Rudel, Ina Scheuerpflug, Roland Barten, Thomas F. Meyer

Journal:

Molecular Microbiology

Year:

1997

Language:

english

File:

PDF, 1.21 MB

english, 1997

26

Gene Transfer and Amplification in CHO Cells : Efficient Methods for Maximizing Specific Productivity and Assessment of Genetic Consequences

FLORIAN M. WURM, ADRIANA JOHNSON, THOMAS RYLL, CHRISTIANE KÖHNE, HARRY SCHERTHAN, FRANK GLAAB, YOLANDA S. LIE, CHRISTOS J. PETROPOULOS, W. ROBERT ARATHOON

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 683 KB

english, 1996

27

Thin-Film Electrodes: Microscopic and Nanoscopic Three-Phase-Boundaries of Platinum Thin Film Electrodes on YSZ Electrolyte (Adv. Funct. Mater. 3/2011)

Thomas Ryll, Henning Galinski, Lukas Schlagenhauf, Pierre Elser, Jennifer L. M. Rupp, Anja Bieberle-Hutter, Ludwig J. Gauckler

Journal:

Advanced Functional Materials

Year:

2011

File:

PDF, 4.44 MB

2011

28

Performance of high intensity fed-batch mammalian cell cultures in disposable bioreactor systems

John Paul Smelko, Kelly Rae Wiltberger, Eric Francis Hickman, Beverly Janey Morris, Tobias James Blackburn, Thomas Ryll

Journal:

Biotechnology Progress

Year:

2011

Language:

english

File:

PDF, 1.25 MB

english, 2011

29

Electrical conductivity and crystallization of amorphous bismuth ruthenate thin films deposited by spray pyrolysis

Ryll, Thomas, Brunner, Andreas, Ellenbroek, Stefan, Bieberle-Hutter, Anja, Rupp, Jennifer L. M., Gauckler, Ludwig J.

Journal:

Physical Chemistry Chemical Physics

Year:

2010

Language:

english

File:

PDF, 1.44 MB

english, 2010

30

Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models

Tescione, Lia, Lambropoulos, James, Paranandi, Madhava Ram, Makagiansar, Helena, Ryll, Thomas

Journal:

Biotechnology and Bioengineering

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

31

Secretion of glycosylation site mutants can be rescued by the signal/pro sequence of tissue plasminogen activator

Christiane Köhne, Adriana Johnson, Sabrina Tom, David H. Peers, Richard L. Gehant, Timothy A. Hotaling, Dave Brousseau, Thomas Ryll, Judith A. Fox, Steven M. Chamow, Phillip W. Berman

Journal:

Journal of Cellular Biochemistry

Year:

1999

Language:

english

File:

PDF, 422 KB

english, 1999

32

Therapeutic Fc-Fusion Proteins || Quality by Design Applied to a Fc-Fusion Protein: A Case Study

Chamow, Steven M., Ryll, Thomas, Lowman, Henry B., Farson, Deborah

Year:

2014

Language:

english

File:

PDF, 1.75 MB

english, 2014

33

Therapeutic Fc-Fusion Proteins || Index

Chamow, Steven M., Ryll, Thomas, Lowman, Henry B., Farson, Deborah

Year:

2014

Language:

english

File:

PDF, 100 KB

english, 2014

34

Development of small scale cell culture models for screening poloxamer 188 lot-to-lot variation

Peng, Haofan, Hall, Kaitlyn M., Clayton, Blake, Wiltberger, Kelly, Hu, Weiwei, Hughes, Erik, Kane, John, Ney, Rachel, Ryll, Thomas

Journal:

Biotechnology Progress

Year:

2014

Language:

english

File:

PDF, 596 KB

english, 2014

35

The impact of trisulfide modification of antibodies on the properties of antibody-drug conjugates manufactured using thiol chemistry

Liu, Renpeng, Chen, Xuan, Dushime, Junia, Bogalhas, Megan, Lazar, Alexandru C., Ryll, Thomas, Wang, Lintao

Journal:

Year:

2017

Language:

english

File:

PDF, 1.08 MB

english, 2017

36

Lanthanum nickelate thin films deposited by spray pyrolysis: Crystallization, microstructure and electrochemical properties

Thomas Ryll, Philipp Reibisch, Lukas Schlagenhauf, Anja Bieberle-Huetter, Max Döbeli, Jennifer L.M. Rupp, Ludwig J. Gauckler

Journal:

Journal of the European Ceramic Society

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

37

Development of chemically defined medium: An optimized shaker flask scale-down model and an efficient screening process

Weiwei Hu, Eddie Rustandi, Yao-Ming Huang, Helena Yusuf-Makagiansar, Thomas Ryll

Journal:

Journal of Biotechnology

Year:

2008

Language:

english

File:

PDF, 327 KB

english, 2008

38

Novel cholesterol feeding strategy enables a high-density cultivation of cholesterol-dependent NS0 cells in linear low-density polyethylene-based disposable bioreactors

Yiwen Tao, Helena Yusuf-Makagiansar, Jennifer Shih, Thomas Ryll, Marty Sinacore

Journal:

Biotechnology Letters

Year:

2012

Language:

english

File:

PDF, 229 KB

english, 2012

39

Therapeutic Fc-Fusion Proteins || Etanercept

Chamow, Steven M., Ryll, Thomas, Lowman, Henry B., Farson, Deborah

Year:

2014

Language:

english

File:

PDF, 703 KB

english, 2014

40

Dealloying of Platinum-Aluminum Thin Films: Dynamics of Pattern Formation

Galinski, Henning, Ryll, Thomas, Schlagenhauf, Lukas, Rechberger, Felix, Ying, Sun, Gauckler, Ludwig J., Mornaghini, Flavio C. F., Ries, Yasmina, Spolenak, Ralph, Döbeli, Max

Journal:

Physical Review Letters

Year:

2011

Language:

english

File:

PDF, 519 KB

english, 2011

41

Dealloying of platinum-aluminum thin films: Electrode performance

Ryll, Thomas, Galinski, Henning, Schlagenhauf, Lukas, Rechberger, Felix, Ying, Sun, Gauckler, Ludwig J., Mornaghini, Flavio C. F., Ries, Yasmina, Spolenak, Ralph, Döbeli, Max

Journal:

Physical Review B

Year:

2011

Language:

english

File:

PDF, 453 KB

english, 2011

42

Integration of cell line and process development to overcome the challenge of a difficult to express protein

Alves, Christina S., Gilbert, Alan, Dalvi, Swati, Germain, Bryan St., Xie, Wenqi, Estes, Scott, Kshirsagar, Rashmi, Ryll, Thomas

Journal:

Biotechnology Progress

Year:

2015

Language:

english

File:

PDF, 941 KB

english, 2015

43

A rapid method for detection of mycoplasmas in mammalian cell cultures and comparison with other routine techniques

Ulrich Valley, Klaus Scharfenberg, Katja Müller, Thomas Ryll, Roland Wagner

Journal:

Enzyme and Microbial Technology

Year:

1995

Language:

english

File:

PDF, 1.21 MB

english, 1995

44

Generation of a cholesterol-independent, non-GS NS0 cell line through chemical treatment and application for high titer antibody production

Jincai Li, Wei Gu, Diane G. Edmondson, Connie Lu, Natarajan Vijayasankaran, Bruno Figueroa, Dave Stevenson, Thomas Ryll, Feng Li

Journal:

Biotechnology and Bioengineering

Year:

2012

Language:

english

File:

PDF, 362 KB

english, 2012

45

Characterization of thin films for solid oxide fuel cells facilitated by micropatterning

Thomas Ryll, Jennifer L.M. Rupp, Anja Bieberle-Hutter, Henning Galinski, Ludwig J. Gauckler

Journal:

Scripta Materialia

Year:

2011

Language:

english

File:

PDF, 505 KB

english, 2011

46

Therapeutic Fc-Fusion Proteins || Analytical Methods Used to Characterize Fc-Fusion Proteins

Chamow, Steven M., Ryll, Thomas, Lowman, Henry B., Farson, Deborah

Year:

2014

Language:

english

File:

PDF, 396 KB

english, 2014

47

Therapeutic Fc-Fusion Proteins || Fc-Fusion Protein Expression Technology

Chamow, Steven M., Ryll, Thomas, Lowman, Henry B., Farson, Deborah

Year:

2014

Language:

english

File:

PDF, 243 KB

english, 2014

48

Towards an intelligent fixturing system with rapid reconfiguration and part positioning

Marco Ryll, Thomas N. Papastathis, Svetan Ratchev

Journal:

Journal of Materials Processing Technology

Year:

2008

Language:

english

File:

PDF, 420 KB

english, 2008

49

A Comparison of Different Methods To Determine the End of Exponential Growth in CHO Cell Cultures for Optimization of Scale-Up

Ilonka Schoenherr, Thomas Stapp, Thomas Ryll

Journal:

Biotechnology Progress

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

50

Therapeutic Fc-Fusion Proteins || Cell Culture-Based Production

Chamow, Steven M., Ryll, Thomas, Lowman, Henry B., Farson, Deborah

Year:

2014

Language:

english

File:

PDF, 645 KB

english, 2014

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